PSI - Issue 65

Available online at www.sciencedirect.com Available online at www.sciencedirect.com ScienceDirect Structural Integrity Procedia 00 (2024) 000–000 Available online at www.sciencedirect.com ScienceDirect Structural Integrity Procedia 00 (2024) 000–000

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Procedia Structural Integrity 65 (2024) 290–294

The 17th International Conference on MECHANICS, RESOURCE AND DIAGNOSTICS OF MATERIALS AND STRUCTURES (MRDMS 2023) Simulation of bioresorption of polymer matrixes for regenerative medicine Polina Tyubaeva a,b , Ivetta Varyan a,b *, Anatoly Popov a,b a Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 Kosygin st., Moscow, 119334, Russian Federation b Plekhanov Russian University of Economics, 36 Stremyanny per., Moscow, 117997, Russian Federation. Abstract The creation of modern biocompatible polymer structures with valuable functional properties based on biodegradable polymers allows us to propose new approaches to obtaining innovative materials to solve biomedical problems. However, the problem of choosing the optimal polymer matrices for regenerative medicine is acute. The work is aimed at expanding the boundaries of ideas about the modeling of bioresorption in various media and the role of supramolecular structure in these processes. Based on the DSC and GPС methods, it is possible to assess the contribution of the supramolecular structure of the polymer, in particular the degree of crystallinity and the state of the amorphous phase in bioresorption in a living organism and in a model environment. © 2024 The Authors, Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of MRDMS 2023 organizers Keywords: regenerative medicine; wound healing; biopolymers; electroforming The 17th International Conference on MECHANICS, RESOURCE AND DIAGNOSTICS OF MATERIALS AND STRUCTURES (MRDMS 2023) Simulation of bioresorption of polymer matrixes for regenerative medicine Polina Tyubaeva a,b , Ivetta Varyan a,b *, Anatoly Popov a,b a Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 Kosygin st., Moscow, 119334, Russian Federation b Plekhanov Russian University of Economics, 36 Stremyanny per., Moscow, 117997, Russian Federation. Abstract The creation of modern biocompatible polymer structures with valuable functional properties based on biodegradable polymers allows us to propose new approaches to obtaining innovative materials to solve biomedical problems. However, the problem of choosing the optimal polymer matrices for regenerative medicine is acute. The work is aimed at expanding the boundaries of ideas about the modeling of bioresorption in various media and the role of supramolecular structure in these processes. Based on the DSC and GPС methods, it is possible to assess the contribution of the supramolecular structure of the polymer, in particular the degree of crystallinity and the state of the amorphous phase in bioresorption in a living organism and in a model environment. © 2024 The Authors, Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of MRDMS 2023 organizers Keywords: regenerative medicine; wound healing; biopolymers; electroforming © 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of MRDMS 2023 organizers

1. Introduction 1. Introduction

Of great interest is the creation of intelligent biomimetic materials for wound healing based on biodegradable and biocompatible polymers and various modifying additives, including growth factors. Creating the fundamental foundations for the development of composite materials based on polymer-modifying additive-protein molecule systems for regenerative medicine is a complex task. Thus, to create effective personalized wound healing agents, it Of great interest is the creation of intelligent biomimetic materials for wound healing based on biodegradable and biocompatible polymers and various modifying additives, including growth factors. Creating the fundamental foundations for the development of composite materials based on polymer-modifying additive-protein molecule systems for regenerative medicine is a complex task. Thus, to create effective personalized wound healing agents, it

* Corresponding author. Tel.: +7-916-983-6394. E-mail address: ivetta.varyan@yandex.ru * Corresponding author. Tel.: +7-916-983-6394. E-mail address: ivetta.varyan@yandex.ru

2452-3216 © 2024 The Authors, Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of MRDMS 2023 organizers 2452-3216 © 2024 The Authors, Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of MRDMS 2023 organizers

2452-3216 © 2024 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of MRDMS 2023 organizers 10.1016/j.prostr.2024.11.043