PSI - Issue 49

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Nataliya Elenskaya et al. / Procedia Structural Integrity 49 (2023) 43–50 Author name / Structural Integrity Procedia 00 (2023) 000–000

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These results illustrate the influence of the structure morphology on the degradation process: the unit cell G shows the most compliant mechanical behaviour, while the change of elastic response for the unit cells types D and I WP during degradation was almost identical. 4. Conclusions This study was focused on the comparison of two methods for modelling of the degradation process of the unit cells of TPMS-based PLA scaffolds subjected to compressive loads. It can be concluded that the results obtained with proposed degradation modelling techniques differ: the volumetric degradation of the elastic material properties is not proportional to the surface degradation with the same degradation coefficient. The effect of the type of degradation and the geometry of the structure on its elastic properties was assessed. These results will be further expanded to study of the degradation processes of bone-tissue engineering scaffolds with more complicated geometry. Acknowledgements The results were obtained within the framework of research project no. FSNM-2023-0003. References Babilotte J, Guduric V, Le Nihouannen D, et al (2019) 3D printed polymer–mineral composite biomaterials for bone tissue engineering: Fabrication and characterization. J Biomed Mater Res Part B Appl Biomater 107:2579–2595. https://doi.org/10.1002/jbm.b.34348 Bracaglia LG, Smith BT, Watson E, et al (2017) 3D printing for the design and fabrication of polymer-based gradient scaffolds. Acta Biomater 56:3–13. https://doi.org/10.1016/j.actbio.2017.03.030 Castro APG, Ruben RB, Gonçalves SB, et al (2019) Numerical and experimental evaluation of TPMS Gyroid scaffolds for bone tissue engineering. Comput Methods Biomech Biomed Engin 22:567–573. https://doi.org/10.1080/10255842.2019.1569638 Dong Z, Zhao X (2021) Application of TPMS structure in bone regeneration. Eng Regen 2:154–162. https://doi.org/10.1016/j.engreg.2021.09.004 Elenskaya N, Tashkinov M (2021a) Modeling of Deformation Behavior of Gyroid and I-WP Polymer Lattice Structures with a Porosity Gradient. Procedia Struct Integr 32:253–260. https://doi.org/10.1016/j.prostr.2021.09.036 Elenskaya N, Tashkinov M (2021b) Numerical simulation of deformation behavior of additively manufactured polymer lattice structures with a porosity gradient. Procedia Struct Integr 37:692–697. https://doi.org/10.1016/j.prostr.2022.01.139 Elenskaya N V., Tashkinov MA, Silberschmidt V V. (2022) Numerical Modeling of the Deformation Behavior of Polymer Lattice Structures with a Density Gradient Based on Additive Technologies. Vestn St Petersbg Univ Math 55:443–452. https://doi.org/10.1134/S1063454122040045 Fan Y-B, Li P, Zeng L, Huang X-J (2008) Effects of mechanical load on the degradation of poly(d,l-lactic acid) foam. Polym Degrad Stab 93:677–683. https://doi.org/10.1016/j.polymdegradstab.2007.12.015 Göpferich A (1996) Mechanisms of polymer degradation and erosion. Biomaterials 17:103–114. https://doi.org/10.1016/0142-9612(96)85755-3 Helder J, Dijkstra PJ, Feijen J (1990) In vitro degradation of glycine/DL-lactic acid copolymers. J Biomed Mater Res 24:1005–1020. https://doi.org/10.1002/jbm.820240804 Jayaraman P, Gandhimathi C, Venugopal JR, et al (2015) Controlled release of drugs in electrosprayed nanoparticles for bone tissue engineering. Adv Drug Deliv Rev 94:77–95. https://doi.org/10.1016/j.addr.2015.09.007 Jodati H, Yılmaz B, Evis Z (2020) A review of bioceramic porous scaffolds for hard tissue applications: Effects of structural features. Ceram Int 46:15725–15739. https://doi.org/10.1016/j.ceramint.2020.03.192 Kanwar S, Vijayavenkataraman S (2021) Design of 3D printed scaffolds for bone tissue engineering: A review. Bioprinting 24:e00167. https://doi.org/10.1016/j.bprint.2021.e00167 Li L, Li J, Guo J, et al (2019) 3D Molecularly Functionalized Cell‐Free Biomimetic Scaffolds for O steochondral Regeneration. Adv Funct Mater 29:1807356. https://doi.org/10.1002/adfm.201807356 Li X, Zou Q, Wei J, Li W (2021) The degradation regulation of 3D printed scaffolds for promotion of osteogenesis and in vivo tracking. Compos Part B Eng 222:109084. https://doi.org/10.1016/j.compositesb.2021.109084 Liu Y, Rath B, Tingart M, Eschweiler J (2020) Role of implants surface modification in osseointegration: A systematic review. J Biomed Mater