PSI - Issue 43

ScienceDirect Available online at www.sciencedirect.com ScienceDirect Structural Integrity Procedia 00 (2022) 000 – 000 Available online at www.sciencedirect.com Sci nceDirect Structural Integrity Procedia 00 (2022) 000 – 000 Available online at www.sciencedirect.com Procedia Structural Integrity 43 (2023) 71–76

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© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under the responsibility of MSMF10 organizers. Abstract For the investigations, scaffolds for bone regeneration (in the form of non-woven mats) were fabricated based on a polymer blend based on polycaprolactone, poly-L-lactic acid and gelatin by electrospinning which were partly modified using vitamin D3 and reinforced with 0 – 12 % nano-hydroxyapatite (nano-HAp extracted from ostrich bones) to improve both biocompatibility and mechanical performance. Electron microscopic approaches were applied to analyse the fiber microstructure due to phase separation and the microdeformation mechanisms after testing, as well as the fiber diameter as a function of the nano-HAp fraction. From uniaxial tensile testing it has been found that incorporation of nano-HAp into the blend triggers the mechanical properties of the scaffolds to a high degree, which results in an increase in tensile strength from 0.7 MPa to 5.6 MPa and an increase in strain at break from 2 % to 37 %. The transition from the very brittle behavior of the neat blend fiber mats to the highly ductile behavior of the blend fiber mats containing 12 % nano-HAp is related to a change in the microdeformation behavior of the nano- or micro-sized fibers. Whereas at lower nano-HAp content, crazing inside the fibers is prominent, thin layer yielding be omes dominan at higher nano-HAp content. Abstract For the investigations, scaffolds for bone regeneration (in the form of non-woven mats) were fabricated based on a polymer blend based on polycaprolactone, poly-L-lactic acid and gelatin by electrospinning which were partly modified using vitamin D3 and reinforced with 0 – 12 % nano-hydroxyapatite (nano-HAp extracted from ostrich bones) to improve both biocompatibility and mechanical performance. Electron microscopic approaches were applied to analyse the fiber microstructure due to phase separation and the microdeformation mechanisms after testing, as well as the fiber diameter as a function of the nano-HAp fraction. From uniaxial tensile testing it has been found that incorporation of nano-HAp into the blend triggers the mechanical properties of the scaffolds to a high degree, which results in an increase in tensile strength from 0.7 MPa to 5.6 MPa and an increase in strain at break from 2 % to 37 %. The transition from the very brittle behavior of the neat blend fiber mats to the highly ductile behavior of the blend fiber mats containing 12 % nano-HAp is related to a change in the microdeformation behavior of the nano- or micro-sized fibers. Whereas at lower nano-HAp content, crazing inside the fibers is prominent, thin layer yielding becomes dominant at higher nano-HAp content. © 20 23 The Authors. Published by Elsevier B.V. 10th International Conference on Materials Structure and Micromechanics of Fracture Correlation between Morphology, Mechanical Properties and Microdeformation Behavior of Electrospun Scaffolds Based on a Biobased Polymer Blend and Biogenic Nano-Hydroxyapatite Komal P. Malla a,b,c , Sven Henning d,f , Ralf Lach e,f* , Herbert Jennissen g , Goerg Michler c,f , Mario Beiner c,d , Rameshwar Adhikari a a Tribhuvan University, Central Department of Chemistry, Kathmandu, Nepal b Pokhara University, Faculty of Health Sciences, Pokhara, Nepal c Martin-Luther-University Halle-Wittenberg, Institute of Physics, Von-Danckelmann-Platz 3, 06120 Halle / Saale, Germany d Fraunhofer Institute for Microstructure of Materials and Systems (IMWS), Walter- Hülse - Straße 1, 06120 Halle / Saale, Germany e Polymer Service GmbH Merseburg (PSM), Geusaer Straße 81f, 06217 Merseburg, Germany f Institute for Polymer Materials e.V. (IPW), Eberhard-Leibnitz- Straße 2, 06217 Merseburg, German y g University of Duisburg- Essen, Department of Biochemical Endocrinology, Institute for Physiological Chemistry, Hufelandstraße 55, 45122 Essen, Germany 10th International Conference on Materials Structure and Micromechanics of Fracture Correlation between Morphology, Mechanical Properties and Microdeformation Behavior of Electrospun Scaffolds Based on a Biobased Polymer Blend and Biogenic Nano-Hydroxyapatite Komal P. Malla a,b,c , Sven Henning d,f , Ralf Lach e,f* , Herbert Jennissen g , Goerg Michler c,f , Mario Beiner c,d , Rameshwar Adhikari a a Tribhuvan University, Central Department of Chemistry, Kathmandu, Nepal b Pokha a Univ rsity, Faculty of Health Sciences, Pok ara, Nepal c Martin-Luther-University Halle-Wittenberg, Institute of Physics, Von-Danckelmann-Platz 3, 06120 Halle / Saale, Germany d Fraunhofer Institute for Microstructure of Materials and Systems (IMWS), Walter- Hülse - Straße 1, 06120 Halle / Saale, Germany e Polymer Service GmbH Merseburg (PSM), Geus er Straße 81f, 06217 Merseburg, Germany f Institute for Polymer Mat rials e.V. (IPW), Eberhard-Leibnitz- Straße 2, 06217 Merseburg, G rm n y g University of Duisburg- Essen, Department of Bioch mical Endocrinology, Institute for Physiological Chemistry, Hufelandstraße 55, 45122 Essen, Germany

© 20 23 The Authors. Published by Elsevier B.V. * Corresponding author. Tel.: 0-000-000-0000 E-mail address: ralf.lach@psm-merseburg.de

2452-3216 © 2023 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under the responsibility of MSMF10 organizers. 10.1016/j.prostr.2022.12.237 2452-3216 © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under the responsibility of MSMF10 organizers. 2452-3216 © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under the responsibility of MSMF10 organizers. * Corresponding author. Tel.: 0-000-000-0000 E-mail address: ralf.lach@psm-merseburg.de