PSI - Issue 40

Available online at www.sciencedirect.com Available online at www.sciencedirect.com Sci nceDirect StructuralIntegrity Procedia 00 (2022) 000 – 000 Available online at www.sciencedirect.com ScienceDirect StructuralIntegrity Procedia 00 (2022) 000 – 000

www.elsevier.com/locate/procedia www.elsevier.com/locate/procedia

ScienceDirect

Procedia Structural Integrity 40 (2022) 12–16

© 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of the scientific committee of the15th International Conference on Mechanics, Resources and Diagnostics of Materials and Structures. Abstract Associations of phenotypic signs of undifferentiated connective tissue dysplasia (UCTD) and bone fractures not related to postmenopausal, senile or glucocorticoid osteoporosis are discussed. A cross-sectional study enrolled 458 persons (143 had a history of fractures). A significant predominance of individuals with fractures in the UCTD group was revealed. Strong positive correlations of the total number of fractures with the number of external signs of UCTD (p<0.0001), internal signs of UCTD (p<0.0001), Beighton joints hypermobility index (p<0.0001) were found. Weak positive correlations of the number of fractures with the height (p=0.02) and arms span (p=0.011), and the personal smoker index (p=0.01) were revealed. © 2022 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of the scientific committee of the15th International Conference on Mechanics, Resource and Diagnostics of Materials and Structures. Keywords: undifferentiated connective tissue dysplasia (UCTD), bone fractures . 15th International Conference on Mechanics, Resource and Diagnostics of Materials and Stru tures Association of peripheral bone fractures and signs of undifferentiated connective tissue dysplasia A. V. Akimova*, V. A. Mironov, A.A. Popov, P.A. Palabugina Ural State Medical University, 3 Repin St., Ekaterinburg, 620028, Russian Federation Abstract Associations of phenotypic signs of undifferentiated connective tissue dysplasia (UCTD) and bone fractures not related to postmenopausal, senile or glucocorticoid osteoporosis are discussed. A cro s-sectional study enrolled 458 perso s (143 had a history of fractures). A significant predominance of individuals with fractures in the UCTD group was revealed. Strong positive correlations of the total number of fractures with the number of external signs of UCTD (p<0.0001), int rnal signs of UCTD (p<0.0001), Beighton joi ts hypermobility index (p<0.0001) were found. Weak positive correlations of th umber of fractures with the height (p=0.02) and arms span (p=0.011), and the personal smoker index (p=0.01) were revealed. © 2022 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review u der responsibility of scientific committe of the15th International Conference o Mechanics, Resource and Diagnostics of Materials and Structur s. Keywords: undifferentiated connective tissue dysplasia (UCTD), bone fractures . 15th International Conference on Mechanics, Resource and Diagnostics of Materials and Structures Association of peripheral bone fractures and signs of undifferentiated connective tissue dysplasia A. V. Akimova*, V. A. Mironov, A.A. Popov, P.A. Palabugina Ural State Medical University, 3 Repin St., Ekaterinburg, 620028, Russian Federation

Nomenclature UCTD undifferentiated connective tissue dysplasia BMD bone mineral density BMI body mass index Nomenclature UCTD undifferentiated connective tissue dysplasia BMD bone miner l density I dy ass in x

* Corresponding author. Tel.: +7-904-98-156-84. E-mail address: anna_v_akimova@mail.ru * Corresponding author. Tel.: +7-904-98-156-84. E-mail address: anna_v_akimova@mail.ru

2452-3216 © 2022 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of the scientific committee of the15th International Conference on Mechanics, Resource and Diagnostics of Materials and Structures. 2452-3216 © 2022 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of the scientific committee of the15th International Conference on Mechanics, Resource and Diagnostics of Materials and Structures.

2452-3216 © 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of the scientific committee of the15th International Conference on Mechanics, Resources and Diagnostics

of Materials and Structures. 10.1016/j.prostr.2022.04.001