PSI - Issue 15

Available online at www.sciencedirect.com Structural Integrity Procedia 00 (2019) 000–000 Available online at www.sciencedirect.com ScienceDirect Structural Integrity Procedia 00 (2019) 000–000 ScienceDirect

www.elsevier.com/locate/procedia

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ScienceDirect

Procedia Structural Integrity 15 (2019) 55–59

© 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) Selection and peer-review under responsibility of International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) Selection and peer-review under responsibility of International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. Abstract Poly-L-lactic acid (PLLA), predominantly used for manufacturing biore orbable polymeric stents, is brittle and has a c nsiderable degradation time (over 2~3 y ars). To address its deficiencies, ne of the employed techniques is to blend it with elastomers, t pically polymers with rubber-like behaviour. The ai of this paper i t assess a co-p lymer developed for tential ardiovascular application to address the limitations of L A. The focus is on char cterisation of mechanical properties of the co-polymer using a spherical nanoindentation technique, in comparis n with those of PLLA. The copoly er i a blended poly(L-lactide-co-e-caprolactone)-poly (ethylene glycol) (PLA-(PCL-PEG)), with weight ratios of 60% d 40% for PLA and PCL-PEG, resp ctively. The nov lty of t is copolymer is th addition of phosphate- glass particles (less than 2 μm i size and 10 wt%), aimi g to toughen the material. The mat rial was supplied in the form of tubing. The obtained nanoindentation results, together with the data of tensile testing, showed that the novel co-polymer (PLA-(PCL-PEG)) did not perform well in comparison to PLLA, and, hence, required further improvements in composition and processing. © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) Selection and peer-review under responsibility of International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019 Experimental Study of Synthesized Co-polymer for Stent Application Raasti Naseem a , Liguo Zhao a, 0F *, Vadim V. Silberschmidt a , Yang Liu a , Xiang Zhang b a Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Epinal Way, Loughborough, LE11 3TU, UK b Lucideon Ltd, Stoke-on-Trent, ST4 7LQ, UK Abstract Poly-L-lactic acid (PLLA), predominantly used for manufacturing bioresorbable polymeric stents, is brittle and has a considerable degradation time (over 2~3 years). To address its deficiencies, one of the employed techniques is to blend it with elastomers, typically polymers with rubber-like behaviour. The aim of this paper is to assess a co-polymer developed for potential cardiovascular application to address the limitations of PLLA. The focus is on characterisation of mechanical properties of the co-polymer using a spherical nanoindentation technique, in comparison with those of PLLA. The copolymer is a blended poly(L-lactide-co-e-caprolactone)-poly (ethylene glycol) (PLA-(PCL-PEG)), with weight ratios of 60% and 40% for PLA and PCL-PEG, respectively. The novelty of this copolymer is the addition of phosphate- glass particles (less than 2 μm in size and 10 wt%), aiming to toughen the material. The material was supplied in the form of tubing. The obtained nanoindentation results, together with the data of tensile testing, showed that the novel co-polymer (PLA-(PCL-PEG)) did not perform well in comparison to PLLA, and, hence, required further improvements in composition and processing. International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019 Experimental Study of Synthes zed Co-polymer for Stent Application Raasti Naseem a , Liguo Zhao a, 0F *, Vadim V. Silberschmidt a , Yang Liu a , Xiang Zhang b a Wolfson School of Mechanical, Electrical and Man facturing Engin ering, Loughborough University, Epinal Way, Loughborough, LE11 3TU, UK b Lucideon Ltd, Stoke-on-Trent, ST4 7LQ, UK Keywords: PLLA; Nanoindentation; Synthesized co-polymer; Modulus; Polymeric stent

Keywords: PLLA; Nanoindentation; Synthesized co-polymer; Modulus; Polymeric stent

* Corresponding author. Tel.: 0044-1509-227799. E-mail address: L.Zhao@Lboro.ac.uk * Corresponding author. Tel.: 0044-1509-227799. E-mail address: L.Zhao@Lboro.ac.uk

2452-3216 © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) Selection and peer-review under responsibility of International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. 2452-3216 © 2019 The Authors. Published b Elsevi r B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) Selection and peer-review under responsibility of International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019.

2452-3216  2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) Selection and peer-review under responsibility of International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. 10.1016/j.prostr.2019.07.011