PSI - Issue 15

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Editorial Liguo Zhao Vadim V Silberschmidt Editorial Liguo Zhao Vadim V Silberschmidt Editorial Liguo Zhao Vadim V Silberschmidt Editorial Liguo Zhao Vadim V Silberschmidt Editorial Liguo Zhao Vadim V Silberschmidt Editorial Liguo Zhao Vadim V Silberschmidt

Procedia Structural Integrity 15 (2019) 1

2452-3216  2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) Selection and peer-review under responsibility of International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. 10.1016/j.prostr.2019.07.001 This issue presents a selection of research papers presented at the International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. The Conference was organised by Technical Committee 14 "Integrity of Biomedical and Biological Materials" of the European Structural Integrity Society (ESIS). The Conference Organisers would like to acknowledge its sponsors: European Structural Integrity Society (ESIS); Engineering and Physical Sciences Research Council (EPSRC), the main funding body for engineering and physical sciences research in the UK; and Loughborough University, UK. Wit in the framework of he Conference, a Special Session “Design, Manufacturing and Evaluation of Shape-memory-alloy Sten s” was o ganis d b partners of the EPSRC UK project (2018-2020): "Smart Peripheral Stents for the Lower Extremity - Design, Manufacturing and Evaluation.” The Session focused on the top s, directly relat d to the proj ct: le on-specific design; additive manufacturing; biomechanical testing; modelling of self-expansion; biocompatibility study; in-v tro haemodynamics; in-vivo evaluation; modelling of deployment; deformations due to severe twisting and bending. This issue presents a selection o research papers presented at the International Conf rence on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. The Conferenc was organised by Technical Committee 14 "Integrity of Biomedical and Bi logical Materials" of the European Structural Integrity ocie y (ESIS). The Conference Organisers would like to acknowledge its sponsors: European Structural I tegrity Society (ESIS); Engi eering and Physical Sciences Res arch Council (EPSRC), the main funding body for engineering and physical sciences research in the UK; and Loughborough University, UK. manufacturing; stent failure and fracture; i -vitro and in-vivo studies; biocompatibility of stents; stent vessel interaction; fluid-solid interaction; in-stent restenosis; biological and clinical issues related to stents; stent deployment and delivery; medical-imaging-based assessment. Within the framework of the Conference, a Special Session “Design, Manufacturing and Evaluation of Shape-memory-alloy Stents” was organis d b partners of the EPSRC UK project (2018-2020): "Smart Peripheral Stents for the Lower Extremity - Design, Manufacturing and Evaluation.” The Session focused on the topics, directly related to the project: lesion-specific design; additive manufacturing; biomechanical testing; modelling of self-expansion; biocompatibility study; in-vitro haemodynamics; in-vivo evaluation; modelling of deployment; deformations due to severe twisting and bending. This issue presents a selection of research papers presented at the International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. The Conferenc was organised by Technical Committee 14 "Integrity of Biomedical and Biological Materials" of the European Structural Integrity ociety (ESIS). The Conference Organisers would like to acknowledge its sponsors: European Structural I tegrity Society (ESIS); Engi eering and Physical Sciences Research Council (EPSRC), the main funding body for engineering and physical sciences research in the UK; and Loughborough University, UK. materials science, experimental mechanics, modelling and various aspects of processing and manufacturing as well as medical practitioners to discuss advances in stent technologies. Over 30 papers presented at the Conference by researchers from 10 countries covered various topics including: metallic and polymeric materials for stents; mechanical properties of stents; development of biodegradable stents; modelling and simulations of stent deformation; stent design; stent manufacturing; stent failure and fracture; in-vitro and in-vivo studies; biocompatibility of stents; stent vessel interaction; fluid-solid interaction; in-stent restenosis; biological and clinical issues related to stents; stent deployment and delivery; medical-imaging-based assessment. Within the framework of the Conference, a Special Session “Design, Manufacturing and Evaluation of Shape-memory-alloy Stents” was organised by partners of the EPSRC UK project (2018-2020): "Smart Peripheral Stents for the Lower Extremity - Design, Manufacturing and Evaluation.” The Session focused on the topics, directly related to the project: lesion-specific design; additive manufacturing; biomechanical testing; modelling of self-expansion; biocompatibility study; in-vitro haemodynamics; in-vivo evaluation; modelling of deployment; deformations due to severe twisting and bending. This issue presents a selection of research papers presented at the International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. The Conference was organised by Technical Committee 14 "Integrity of Biomedical and Biological Materials" of the European Structural Integrity Society (ESIS). The Conference Organisers would like to acknowledge its sponsors: European Structural Integrity Society (ESIS); Engineering and Physical Sciences Research Council (EPSRC), the main funding body for engineering and physical sciences research in the UK; and Loughborough University, UK. Stenosis refers to a partial or total blockage of arteries caused by accumulation of fatty deposits on the vessel wall. The disease results in a progressive damage to patients’ health and wellbeing due to the restriction of blood supply to muscles and organs. For instance, coronary-artery stenosis is a leading reason of heart attack, while peripheral-artery stenosis causes pain when walking and tissue death of a leg. The disease can be effectively treated with vascular stents, which are essentially meshes of synthetic materials used to reopen the blocked blood vessels. However, stenting in arteries proved problematic and challenging, given the complexity of the arterial disease and constant exposure of stents to biomechanical forces and physiological environment. Consequently, it requires continuous research and development, in terms f material, design and manufacturing technologies, in order to improve patency times and reduce complications in interventional therapy. To address these challenges, an International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019 was held on 15-17 July 2019 at Loughborough University London, UK. The aim of this Conference was to bring together specialists in biomedical engineering, biomechanics, aterials science, experimental mechanics, odelling and various aspects of processing and manufacturing as well as medical practitioners to discuss advances in stent technologies. Over 30 papers presented at the Conference by researchers from 10 countries covered various topics including: metallic and polymeric materials for stents; mechanical properties of stents; development of biodegradable stents; modelling and si ulations of stent deformation; stent design; stent manufacturing; stent failure and fracture; i -vitro and i -vivo studies; biocompatibility of stents; stent vessel interaction; fluid-solid interaction; in-stent restenosis; biological and clinical issues related to stents; stent deployment and delivery; medical-imaging-based assessment. Within the framework of the Conference, a Special Session “Design, Manufacturing and Evaluation of Shape-memory-alloy Stents” was organised b partners of the EPSRC UK project (2018-2020): "Smart Peripheral Stents for the Lower Extremity - Design, Manufacturing and Evaluation.” The Session focused on the topics, directly related to the project: lesion-specific design; additive manufacturing; biomechanical testing; modelling of self-expansion; biocompatibility study; in-vitro haemodynamics; in-vivo evaluation; modelling of deployment; deformations due to severe twisting and bending. This issue presents a selection of research papers presented at the International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. The Conference was organised by Technical Committee 14 "Integrity of Biomedical and Biological Materials" of the European Structural Integrity Society (ESIS). The Conference Organisers would like to acknowledge its sponsors: European Structural Integrity Society (ESIS); Engineering and Physical Sciences Research Council (EPSRC), the main funding body for engineering and physical sciences research in t e UK; and Loughborough University, UK. Stenosis ref rs to a p rtial or total blockage of arteries caused by accumulation of fatty deposits on the vessel wall. The disease results in a progressive damage to patients’ health and wellbeing due to the stricti n of blood supply to muscl s and o gans. For instance, coronary-artery ste os is a le ding r ason of heart attack, while peripheral-artery stenosis causes pain when walking and tissue death of a l g. The disease can be effectively tr ated with vascular stents, whi h are essentially meshes of synth tic materials us d to reopen the blocked blood vessels. However, stenting in arteries proved problemat c and challenging, given t e c mplexity of the arterial disease and constant exp sure f stents to biomechanical forces and physi logical nvironment. Consequently, it requires continuous research and developme t, in terms f material, design and ma ufacturing technologies, in order to improve patency times and reduce complications in interventional therapy. To address these challenges, an Int rnational Conference on Stents: Materials, M chanics and Manufacturi g ICS3M 2019 was held on 15-17 July 2019 at Loughborough Univ rsity London, UK. The aim of this Conferenc w s to bring together specialists in biomedical engineering, bi mechanics, teri ls science, experimental mechanics, odelling and various aspects of processing and manufacturing as well as medical practitioners to discuss advances in stent technologies. Over 30 papers presented at the C nference by researchers from 10 countries covered various topics including: metallic a d polymeric materials for tents; mechanical prope ties f stents; development of biodegradable stents; modelli g and si ulations of stent def rmation; stent design; stent manufactu ing; stent failure and f ure vitro and i -v vo studies; biocompatibil ty of st nts; stent vessel interacti n; fluid-solid interaction; in-stent restenosis; biological and clinical issues related to stents; stent deployment and delivery; medical-imaging-based assessment. Wit in the framework of the Conference, a Special Session “Design, Manufacturing and Evaluation of Shape-memory-alloy Sten s” was o ganised by partners of the EPSRC UK project (2018-2020): "Smart Peripheral S ents for the Lower Extremity - Design, Manufacturing and Evaluation.” The Session focused on the topics, directly relat d to the proj ct: lesi n-specific design; additive manufacturing; biomechanical testing; modelling of self-expansion; bioc mpatibility study; in-vitro haemodynami s; in-vivo evaluation; modelling of deploym nt; deformations due to severe twisting and bending. This issue pr sents a selection o research papers presented t the Int rnational Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. Th Conferenc was organised by Technical Committee 14 "Integrity of Biomedical and Bi logical Materials" of the European Structural Integrity ociety (ESIS). The Conference Organisers would like to acknowledge its sponsors: European Structural I tegrity Society (ESIS); Engi eering and Physical Sciences Res arch Council (EPSRC), the main funding body for engineering and physical sciences research in the UK; and Loughborough University, UK. Stenosis refers to a partial or total blockage of arteries caused by accumulation of fatty deposits on the vessel wall. The disease results in a progressive damage to patients’ health and wellbeing due to the restriction of blood supply to muscles and organs. For instance, coronary-artery stenosis is a leading reason of heart attack, while peripheral-artery stenosis causes pain when walking and tissue death of a leg. The disease can be effectively treated with vascular stents, which are essentially meshes of synthetic materials used to reopen the blocked blood vessels. However, stenting in arteries proved problematic and challenging, given the complexity of the arterial disease and constant exposure of stents to biomechanical forces and physiological environment. Consequently, it requires continuous research and development, in terms of material, design and manufacturing technologies, in order to improve patency times and reduce complications in interventional therapy. To address these challenges, an International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019 was held on 15-17 July 2019 at Loughborough University London, UK. The aim of this Conference was to bring together specialists in biomedical engineering, biomechanics, materials science, experimental mechanics, modelling and various aspects of processing and manufacturing as well as medical practitioners to discuss advances in stent technologies. Over 30 papers presented at the Conference by researchers from 10 countries covered various topics including: metallic and polymeric materials for stents; mechanical properties of stents; development of biodegradable stents; modelling and simulations of stent deformation; stent design; stent manufacturing; stent failure and fracture; in-vitro and in-vivo studies; biocompatibility of stents; stent vessel interaction; fluid-solid interaction; in-stent restenosis; biological and clinical issues related to stents; stent deployment and delivery; medical-imaging-based assessment. Within the framework of the Conference, a Special Session “Design, Manufacturing and Evaluation of Shape-memory-alloy Stents” was organised by partners of the EPSRC UK project (2018-2020): "Smart Peripheral Stents for the Lower Extremity - Design, Manufacturing and Evaluation.” The Session focused on the topics, directly related to the project: lesion-specific design; additive manufacturing; biomechanical testing; modelling of self-expansion; biocompatibility study; in-vitro haemodynamics; in-vivo evaluation; modelling of deployment; deformations due to severe twisting and bending. Stenosis refers to a p rtial or otal blockage of arteries caused by accumulation of fatty deposits on the v ssel wall. The disease results in a progressive damage to patients’ health and wellbeing due to the striction of blood supply to muscles and organs. For instance, coronary-artery stenos is a l ding r ason of heart attack, while peripheral-artery stenosis causes pain when walking and tissue death of a leg. The disease can be effectively tr ated with vascular stents, which are essentially meshes f synth tic materials us d to reopen the bl cked blood vessels. Howev r, ste ting in r eries proved problemat c and challenging, given the complexity of the arterial di ease and constant exp sure f stents to biom chanical forces and physiological nvironment. Consequently, it requ res continuous research and developme t, in terms f mater al, design and ma ufacturing technologies, in order to improve patency times and reduce complications in interventional therapy. To address these challenges, an Int rnational Conference on Stents: Materials, M chanics and Manufacturing I S3M 2019 was held on 15-17 July 2019 at Loughborough Univ sity London, UK. The a m of this Conferenc w s to bring together specialists in biomedi al engineering, biomechanics, teri ls science, experimental mechanics, modell ng and various aspects of processing and manufacturing as well as medical practitioners to discuss advances in stent technologies. Over 30 papers presented at the Conference by researchers from 10 countries covered various topics including: metallic and polymeric materials for stents; mechanical properties f stents; development of biodegradable stents; mod lli g and simulations of stent def rmation; stent design; s ent manufac u ing; stent failure and fra ure i vitro and in-v vo studies; biocompatibility of st nts; s ent vessel interaction; fluid-solid interaction; in-stent restenosis; biological and clinical issues related to stents; stent deployment and delivery; medical-imaging-based assessment. Stenosis refers to a p rtial or total blockage of arteries caused by accumulation of fatty deposits on the vessel wall. The disease results in a progressive damage to patients’ health and wellbeing due to the restriction of blood supply to muscles an organs. For instance, coronary-artery stenosi is a l ding r ason of heart attack, while peripheral-artery stenosis causes pain when walking and tissue death of a leg. The disease can be effectively treated with vascular tents, which are ssentially meshes f synthetic materials us d to reopen the blocked blood vessels. However, stenting in rteries proved problematic and challenging, given t e complexity of the arterial disease and constant exp sure f stents to biomechanical forces and physiological environment. Consequently, it requires continuous research and development, in terms of material, design and manufacturing technologies, in order to improve patency times and reduce complications in interventional therapy. o address these challenges, an Int rnational Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019 was held on 15-17 July 2019 at Loughborough Univ rsity London, UK. The aim of this Conference was to bring together specialists in biomedical engineering, biomechanics, teri ls science, experimental mechanics, modelling and various aspects of processing and anufacturing as well as medical practitioners to discuss advances in stent technologies. Over 30 papers presented at the Conference by researchers from 10 countries covered various topics including: metallic and polymeric materials for stents; mechanical properties of stents; development of biodegradable stents; modelli g and simulations of stent deformation; stent design; stent Stenosis refers to a partial or total blockage of arteries caused by accumulation of fatty deposits on the vessel wall. The disease results in a progressive damage to patients’ health and wellbeing due to the restriction of blood supply to muscles and organs. For instance, coronary-artery stenosis is a leading reason of heart attack, while peripheral-artery stenosis causes pain when walking and tissue death of a leg. The disease can be effectively treated with vascular stents, which are essentially meshes of synthetic materials used to reopen the blocked blood vessels. However, stenting in arteries proved problematic and challenging, given the complexity of the arterial disease and constant exposure of stents to biomechanical forces and physiological environment. Consequently, it requires continuous research and development, in terms of material, design and manufacturing technologies, in order to improve patency times and reduce complications in interventional therapy. To address these challenges, an International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019 was held on 15-17 July 2019 at Loughborough University London, UK. The aim of this Conference was to bring together specialists in biomedical engineering, biomechanics, Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK E-mail: L.Zhao@Lboro.ac.uk; V.Silberschmidt@Lboro.ac.uk Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough Unive sity, Loughborough, Leicestershire, LE11 3TU, UK E-mail: L.Zhao@Lboro.ac.uk; V.Silberschmidt@Lboro.ac.uk Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK E-mail: L.Zhao@Lboro.ac.uk; V.Silberschmidt@Lboro.ac.uk Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK E-mail: L.Zhao@Lboro.ac.uk; V.Silberschmidt@Lboro.ac.uk Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK E-mail: L.Zhao@Lboro.ac.uk; V.Silberschmidt@Lboro.ac.uk Wolfson School of Mechanical, Electrical and Manufa turing Engineering, Loughborough Unive sity, Loughborough, Leicestershire, LE11 3TU, UK E-mail: L.Zhao@Lboro.ac.uk; V.Silberschmidt@Lboro.ac.uk