PSI - Issue 52

First page Table of contents Previous page 647 Next page Last page

ScienceDirect Structural Integrity Procedia 00 (2022) 000 – 000 Structural Integrity Procedia 00 (2022) 000 – 000 Available online at www.sciencedirect.com Available online at www.sciencedirect.com ^ĐŝĞŶĐĞ ŝƌĞĐƚ Available online at www.sciencedirect.com ^ĐŝĞŶĐĞ ŝƌĞĐƚ

www.elsevier.com/locate/procedia www.elsevier.com/locate/procedia

Procedia Structural Integrity 52 (2024) 410–417

© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of Professor Ferri Aliabadi Abstract One method of treating diabetic foot ulcers (DFU), especially superficial and deep ulcers, is by using a wound scaffold in the form of a hydrogel. Sericin derived from silkworm cocoons is a promising hydrogel material candidate. Sericin protein is a part of silk that is rarely used but has the potential for biocompatibility, biological activities, and is easy to process. One of the drawbacks of sericin hydrogels is their lower mechanical properties. Therefore, sericin was composited with PVA through the freeze-thaw technique to obtain a hydrogel with good stability. Sericin/PVA hydrogel was prepared with variations in solution concentration and the ratio of PVA and sericin. It resulted in the hydrogel with interconnected pore structures. Hydrogel-based wound dressings are often chosen for the treatment of DFU in combination with herbal extract. Moringa oleifera leaves extract was embedded into sericin/PVA hydrogel as a substance to heal DFU. In this study, the morphological and structural properties of sericin/PVA hydrogels were evaluated. The micro-CT imaging analysis was done to confirm hydrogel structure and calculate its porosity percentage. The compression test and hyperelasticity validity test were done to validate the hyperelastic material model. © 2023 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Fracture, Damage and Structural Health Monitoring Porous Sericin/PVA/ Moringa oleifera Hydrogels: Physical Properties and Hyperelastic Model Dita Puspitasari a , Ahmad M. Anwar b , Della S. G. Ananda b , Ghullam Reza c , Annisa Jusuf c , Lia A. T. W. Asri b * a Department of Biomedical Engineering, School of Electrical Engineering, Telkom University, Jl. Telekomunikasi 1, Kab. Bandung 40257, Indonesia l. Teknologi Bandung, J Materials Science and Engineering Research Group, Faculty of Mechanical and Aerospace Engineering, Institut b Ganesha no. 10, Bandung 40132, Indonesia a no. 10, Lightweight Structure Research Group, Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Jl. Ganesh c Bandung 40132, Indonesia Abstract One method of treating diabetic foot ulcers (DFU), especially superficial and deep ulcers, is by using a wound scaffold in the form of a hydrogel. Sericin derived from silkworm cocoons is a promising hydrogel material candidate. Sericin protein is a part of silk that is rarely used but has the potential for biocompatibility, biological activities, and is easy to process. One of the drawbacks of sericin hydrogels is their lower mechanical properties. Therefore, sericin was composited with PVA through the freeze-thaw technique to obtain a hydrogel with good stability. Sericin/PVA hydrogel was prepared with variations in solution concentration and the ratio of PVA and sericin. It resulted in the hydrogel with interconnected pore structures. Hydrogel-based wound dressings are often chosen for the treatment of DFU in combination with herbal extract. Moringa oleifera leaves extract was embedded into sericin/PVA hydrogel as a substance to heal DFU. In this study, the morphological and structural properties of sericin/PVA hydrogels were evaluated. The micro-CT imaging analysis was done to confirm hydrogel structure and calculate its porosity percentage. The compression test and hyperelasticity validity test were done to validate the hyperelastic material model. © 2023 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of Professor Ferri Aliabadi Keywords: sericin; hydrogel; scaffold; hyperelastic model; finite element Fracture, Damage and Structural Health Monitoring Porous Sericin/PVA/ Moringa oleifera Hydrogels: Physical Properties and Hyperelastic Model Dita Puspitasari a , Ahmad M. Anwar b , Della S. G. Ananda b , Ghullam Reza c , Annisa Jusuf c , Lia A. T. W. Asri b * a Department of Biomedical Engineering, School of Electrical Engineering, Telkom University, Jl. Telekomunikasi 1, Kab. Bandung 40257, Indonesia l. Teknologi Bandung, J Materials Science and Engineering Research Group, Faculty of Mechanical and Aerospace Engineering, Institut b Ganesha no. 10, Bandung 40132, Indonesia a no. 10, Lightweight Structure Research Group, Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Jl. Ganesh c Bandung 40132, Indonesia Peer-review under responsibility of Professor Ferri Aliabadi Keywords: sericin; hydrogel; scaffold; hyperelastic model; finite element

* Corresponding author. Tel.: +62-22-250-8144 E-mail address: lia.asri@material.itb.ac.id * Corresponding author. Tel.: +62-22-250-8144 E-mail address: lia.asri@material.itb.ac.id

2452-3216 © 2023 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of Professor Ferri Aliabadi 2452-3216 © 2023 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of Professor Ferri Aliabadi

Made with FlippingBook Annual report maker