PSI - Issue 40

Vasily V. Gagiev et al. / Procedia Structural Integrity 40 (2022) 162–165 Vasily V. Gagiev at al. / Structural Integrity Procedia 00 (2022) 000 – 000

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Table 1. Comparison of the RCG indicators of HRV in TC patients aged 56.5±12.58, (upper line, n=8) and healthy people aged 50.44±14.98 (lower line, n=47)

PWC 1 120 treadmill test up to HR 120

RCG indicators (M  ), %, s

Ph, initial background in the supine position

Vm, Valsalva maneuver

рА, Aschner test

Aор, active orthotest

RR (NN), average interval, s

0.781±0.129 0.980±0.042 t=4.32* 0.018±0.006 0.052±0.006 t=6.8* 0.028±0.016 0.072±0.001 t=8.8* 0.011±0.005 0.031±0.004 t=11.1* 0.007±0.005 0.024±0.003 t=10.0* 45.23±16.04 36.8±4.9 t=1.44 13.37±5.94 23.76±3.6 t=4.65* 41.38±14.51 39.41±4.8 t=0.37

0.784±0.140 0.862±0.007 t=0.61 0.017±0.006 0.047±0.006 t=13.6* 0.030±0.015 0.064±0.002 t=6.8* 0.012±0.004 0.026±0.003 t=10.0* 0.007±0.005 0.019±0.003 t=2.83* 0.011±0.009 0.031±0.004 t=10.0* 32.43±18.67 32.2±3.2 t=0.03 14.03±0.835 24.3±2.8 t=20.54* 39.53±19.11 41.8+2.4 t=0.33

0.705±0.162 0.996±0.042 t=6.4* 0.018±0.008 0.070±0.008 t=17.3* 0.013±0.017 0.080±0.012 t=10.8* 0.026±0.016 0.050±0.006 t=4.8* 0.011±0.007 0.031±0.005 t=8.69* 0.011±0.006 0.033±0.005 t=10.0* 37.39±12.66 51.68±5.07 t=3.14* 11.03±4.65 23.92±4.49 t=6.71*

0.660±0.104 0.780±0.036 t=3.42* 0.019±0.010 0.050±0.004 t=8.85* 0.015±0.009 0.051±0.005 t=4.0* 0.018±0.010 0.032±0.004 t=4.0* 0.010±0.006 0.030±0.003 t=10.0* 0.008±0.004 0.021±0.002 t=9.28* 71.98±6.83 41.94±5.09 t=11.9* 14.14±7.37 38.65±4.99 t=9.04* 13.87±12.43 19.41±3.04 t=3.51*

0.706±0.383 0.933±0.044 t=1.69 0.027±0.017 0.066±0.044 t=4.49* 0.043±0.026 0.089±0.001 t=15.3* 0.017±0.007 0.039±0.006 t=11.0* 0.010±0.005 0.028±0.004 t=12.8* 0.015±0.010 0.036±0.004 t=6.0* 28.98±26.78 40.45±5.77 t=1.09 7.79±6.62 23.75±5.09 t=6.51* 46.55±35.10 35.79±5.4 t=0.86

σRR (SDNN), rms deviation, s

ARA, amplitude of respiratory arrhythmia, s

σ l , rms deviation

σ m , rms deviation

σ s , rms deviation

0.008±0.004 0.032±0.004 t=16.0*

σ l , spectral share (VLF%), %, s

σm, spectral share (LF%), %, s

σ s , spectral share (HF%), %

51.57±9.7 24.4±3.81 t=7.85*

The TC subgroup differs from the healthy people by heart rhythm stabilization (SDNN) and increased humoral metabolic component (σ l , σ l %) in the energy spectrum of the wave structure of the rhythm. In 1978 in his article published in the British Medicine journal D. Ewing, among other things, described such stabilization in diabetes patients after prospective studies and detected a high risk of lethality. This stabilization was termed the cardiac autonomic neuropathy syndrome. As a rule, this syndrome accompanies the hardest forms of diseases (cancer, diabetes, cardiac insufficiency, etc.). 4. Conclusion The study has revealed differences in the state of autonomic rhythm regulation in patients with thyroid cancer, namely decreased total variability of all rhythm waves, increased humoral metabolic effects with a significant decrease in sympathetic and parasympathetic ones as compared to those in the healthy people. The detected changes in autonomic regulation may be characteristic of the oncologic pathology of the thyroid gland. Yet, the syndrome of cardiac autonomic neuropathy is polyetiological. It generally occurs under severe pathology. In some cases cardiac autonomic neuropathy can be immediately caused by the dystrophy of the pacemaker cells of the sinoatrial node, their refractoriness and the loss of the autonomic regulation of the sinoatrial node with the transition of heart rhythm regulation to a slow level of humoral metabolic regulation. The presence of these changes reflects the severity of the condition.