PSI - Issue 65

Polina Tyubaeva et al. / Procedia Structural Integrity 65 (2024) 290–294 Polina Tyubaeva, Ivetta Varyan, Anatoly Popov / Structural Integrity Procedia 00 (2024) 000–000

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the types of organisms involved in biodegradation, environmental conditions including heat, humidity, nutrient reserves, temperature, pH, and others by Altaee et al. (2016). Moreover, the kinetics of polymer biodegradation largely depends on the properties of the polymers themselves, including hydrophilicity, degree of surface development, crystallinity, additives, purity, molar mass, enzymatic selectivity, solubility and chemical activity of decomposition products or oligomers by Mohanan et al. (2020) and by Abou-Zeid et al. (2001). It is generally believed that the process of polymer biodegradation includes 3 stages: (1) transition from a high-molecular compound to monomers and oligomers; (2) transition from monomers and oligomers to biomass; (3) transition from biomass to CO 2 and H 2 O by Tosin et al. (2019). However, it is important to note that the problem of studying biodegradable polymer systems lies in the complex and complex nature of the polymer's interaction with biological media. For each polymer, the priority at the stage of creating bioresorbable materials is to establish the degradation period and determine the group of resistance of the polymer matrix to the biological environment. Thus, polymer materials can be combined into three groups of objects in terms of resistance to biological media from the point of view of controlling the rate of degradation: (1) polymer matrixes resistant to the biological environment for a long time; (2) polymer matrixes with low resistance to biological media and rapidly degrading within a short time; (3) Polymer matrixes with controlled resistance to biological media by Altaee et al. (2016). The assignment to a particular group is provided by a combination of key characteristics of the polymer: structural and structural features, the presence of hydrolysable functional groups, in particular the number of polar groups in the polymer structure, providing affinity for water, the ability of the polymer to sorption and diffusion. Thus, from the established data, as well as the requirements for the process of polymer destruction in contact with living media, it follows that one of the key aspects regarding the polymer matrix will be precisely the nature of the supramolecular structure (glass transition temperature and fraction of the crystalline phase). Based on the data obtained, key parameters for modeling the biodegradation of polymer matrixes with various properties and structure features were identified, key patterns were formulated that can be applied as a recommendation for the development of effective means for regenerative medicine, using the example of healing skin wounds, including wounds with a large area of damage. In the process of degradation of the polymer matrix, regardless of its structural features, the following play an important role: the temperature of the reaction medium; the reaction mechanism; diffusion of the degradation initiator into the polymer matrix. The temperature in the case of wound healing cannot exceed the subfebrile temperature (37-38 ° C), which imposes significant restrictions on the range of polymers used for effective wound healing, taking into account the need for rapid resorption of the polymer layer as it heals (up to 100 days in the most difficult cases, usually 15-30 days for skin wounds). 4. Conclusion

Acknowledgements

The materials under investigation were studied with the equipment of the common use centers at the Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences and the Plekhanov Russian University of Economics.

References

Tyubaeva, P., Varyan, I., Nikolskaya, E., Mollaeva, M., Yabbarov, N., Sokol, M., Chirkina, A., Popov, A. 2023. Biocompatibility and Antimicrobial Activity of Electrospun Fibrous Materials Based on PHB and Modified with Hemin. Nanomaterials 13(2), 236. Gasparyan, K., Tyubaeva, P., Varyan, I., Vetcher, A., Popov, A. 2023. Assessing the Biodegradability of PHB-Based Materials with Different Surface Areas: A Comparative Study on Soil Exposure of Films and Electrospun Materials. Polymers 15(9), 2042. Kandhasamy, S., Perumal, S., Madhan, B., Umamaheswari, N., Banday, G., Perumal, P, Santhanakrishnan, V. 2023. Synthesis and Fabrication of Collagen-Coated Ostholamide Electrospun Nanofiber Scaffold for Wound Healing. A. ACS Applied Materials & Interfaces 9(10). Sikorska, W., Musioł, M., Zawidlak-Wȩgrzyńska, B., Rydz, J. 2021. End-of-Life Options for (Bio)degradable Polymers in the Circular Economy. Advances in Polymer Technology. Altaee, N., El-Hiti, G., Fahdil, A., Sudesh, K., Yousif, E., 2016. Biodegradation of different formulations of polyhydroxybutyrate films in soil. Springerplus 5, 762.