PSI - Issue 65

ScienceDirect Available online at www.sciencedirect.com ScienceDirect Structural Integrity Procedia 00 (2024) 000–000 Available online at www.sciencedirect.com ScienceDirect Structural Integrity Procedia 00 (2024) 000–000 Available online at www.sciencedirect.com

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Procedia Structural Integrity 65 (2024) 92–96

The 17th International Conference on MECHANICS, RESOURCE AND DIAGNOSTICS OF MATERIALS AND STRUCTURES (MRDMS 2023) Numerical study of the shock wave effect on tumour in bone tissue Galina Eremina a , Alexey Smolin a, * a Institute of Strength Physics and Materials Science SB RAS, pr. Akademicheskiy 2/4, Tomsk, 634055, Russia Cancer diseases significantly worsen the quality of life of people. Recent studies have shown that relatively small values of compressive stress over 40 kPa lead to growth and migration of cancer cells, while large amplitude can lead to tumour growth arrest. In this work, a mesomodel of a spherical cancer tumour placed in a cubic bone matrix was developed. The influence of loads on the stress-strain state (hydrostatic pressure) is analyzed. The working range of therapy shock wave treatment for stopping tumor growth without damaging surrounding tissues has been determined. © 2024 The Authors, Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of MRDMS 2023 organizers Keywords: shock wave treatment, tumour, biomechanics, physiological loads, simulation, movable cellular automaton method Osteosarcoma is considered to be one of the types of cancer most capable of active development of metastatic cascade (Jiang et al., 2022). Low-intensity external mechanical stimulation leads to increased proliferation of cancer cells in primary and secondary tumour foci as shown in the article Riehl et al. (2021). This fact is explained by the fact that bone tissue has attractive physical properties that facilitate tumour invasion Operea-Lager et al. (2021), Pagnotti et al. (2021). Recent studies have shown that relatively small values of compressive stress over 40 kPa lead to growth and migration of cancer cells, and large amplitude can lead to cessation of tumour growth Briggs et al. (2024). According to mechanobiological principles described in Wang et al. (2017) differentiation of bone tissue cells is caused by compressive stresses in the range from 3 kPa to 0.15 MPa. If we compare it with experimental data on mechanical stimuli for the development or arrest of the neoplastic process, then we can distinguish a range for The 17th International Conference on MECHANICS, RESOURCE AND DIAGNOSTICS OF MATERIALS AND STRUCTURES (MRDMS 2023) Numerical study of the shock wave effect on tumour in bone tissue Galina Eremina a , Alexey Smolin a, * a Institute of Strength Physics and Materials Science SB RAS, pr. Akademicheskiy 2/4, Tomsk, 634055, Russia Abstract Cancer diseases significantly worsen the quality of life of people. Recent studies have shown that relatively small values of compressive stress over 40 kPa lead to growth and migration of cancer cells, while large amplitude can lead to tumour growth arrest. In this work, a mesomodel of a spherical cancer tumour placed in a cubic bone matrix was developed. The influence of loads on the stress-strain state (hydrostatic pressure) is analyzed. The working range of therapy shock wave treatment for stopping tumor growth without damaging surrounding tissues has been determined. © 2024 The Authors, Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of MRDMS 2023 organizers Keywords: shock wave treatment, tumour, biomechanics, physiological loads, simulation, movable cellular automaton method 1. Introduction Osteosarcoma is considered to be one of the types of cancer most capable of active development of metastatic cascade (Jiang et al., 2022). Low-intensity external mechanical stimulation leads to increased proliferation of cancer cells in primary and secondary tumour foci as shown in the article Riehl et al. (2021). This fact is explained by the fact that bone tissue has attractive physical properties that facilitate tumour invasion Operea-Lager et al. (2021), Pagnotti et al. (2021). Recent studies have shown that relatively small values of compressive stress over 40 kPa lead to growth and migration of cancer cells, and large amplitude can lead to cessation of tumour growth Briggs et al. (2024). According to mechanobiological principles described in Wang et al. (2017) differentiation of bone tissue cells is caused by compressive stresses in the range from 3 kPa to 0.15 MPa. If we compare it with experimental data on mechanical stimuli for the development or arrest of the neoplastic process, then we can distinguish a range for © 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of MRDMS 2023 organizers Abstract 1. Introduction

* Corresponding author. Tel.: +7 923 425 6902. E-mail address: anikeeva@ispms.ru * Corresponding author. Tel.: +7 923 425 6902. E-mail address: anikeeva@ispms.ru

2452-3216 © 2024 The Authors, Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of MRDMS 2023 organizers 2452-3216 © 2024 The Authors, Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of MRDMS 2023 organizers

2452-3216 © 2024 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of MRDMS 2023 organizers 10.1016/j.prostr.2024.11.014