PSI - Issue 49

ScienceDirect Structural Integrity Procedia 00 (2023) 000–000 Structural Integrity Procedia 00 (2023) 000–000 Available online at www.sciencedirect.com Available online at www.sciencedirect.com ScienceDirect Available online at www.sciencedirect.com ScienceDirect

www.elsevier.com/locate/procedia www.elsevier.com/locate/procedia

Procedia Structural Integrity 49 (2023) 43–50

© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of ICMD3M 2023 organizers Abstract Artificial porous scaffolds are used in biomedical applications to sustain or replace damaged biological tissues. Embedded into a body, such scaffolds become involved in many physical and biological processes, with degradation and dissolution of the scaffold material being among the most important. Parameters of degradation depends, first of all, on material properties as well as on the properties of the surrounding tissues. It can drastically change the initial mechanical properties of scaffolds. The aim of this work is to investigate the change in effective mechanical properties of polylactide (PLA) porous scaffolds, with morphology based on triply periodic minimum surfaces (TPMS) during degradation and simultaneous compressive loading. Two strategies for modelling of scaffold degradation processes - volumetric and surface degradation - are proposed. Fundamental differences in the proposed approaches are identified and the effects of different types of scaffold morphology on changes in effective elastic properties evaluated. The present study may be useful for design of optimal TPMS scaffold structures taking into account the effect of degradation process on their structural integrity. © 2023 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of ICMD3M 2023 organizers Keywords: Scaffold degradation, triply periodical minimal surfaces, mathematical modeling, finite element method 1. Introduction Materials and structures with complex morphology have great prospects in the field of tissue engineering and surgery, as well as in the development of bio-fabricated artificial organs (Bracaglia et al. 2017; Li et al. 2019; Babilotte Medical Devices: Materials, Mechanics and Manufacturing Numerical strategies for modelling of the degradation process in TPMS-based polymer scaffolds Nataliya Elenskaya a* , Polina Koryagina a , Mikhail Tashkinov a , Vadim V. Silberschmidt b a Perm National Research Polytechnic University, Komsomoslky Ave. 29, Perm 614990, Russia b Loughborough University, Loughborough, Leicestershire LE11 3TU, UK Abstract Artificial porous scaffolds are used in biomedical applications to sustain or replace damaged biological tissues. Embedded into a body, such scaffolds become involved in many physical and biological processes, with degradation and dissolution of the scaffold material being among the most important. Parameters of degradation depends, first of all, on material properties as well as on the properties of the surrounding tissues. It can drastically change the initial mechanical properties of scaffolds. The aim of this work is to investigate the change in effective mechanical properties of polylactide (PLA) porous scaffolds, with morphology based on triply periodic minimum surfaces (TPMS) during degradation and simultaneous compressive loading. Two strategies for modelling of scaffold degradation processes - volumetric and surface degradation - are proposed. Fundamental differences in the proposed approaches are identified and the effects of different types of scaffold morphology on changes in effective elastic properties evaluated. The present study may be useful for design of optimal TPMS scaffold structures taking into account the effect of degradation process on their structural integrity. © 2023 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of ICMD3M 2023 organizers Keywords: Scaffold degradation, triply periodical minimal surfaces, mathematical modeling, finite element method 1. Introduction Materials and structures with complex morphology have great prospects in the field of tissue engineering and surgery, as well as in the development of bio-fabricated artificial organs (Bracaglia et al. 2017; Li et al. 2019; Babilotte Medical Devices: Materials, Mechanics and Manufacturing Numerical strategies for modelling of the degradation process in TPMS-based polymer scaffolds Nataliya Elenskaya a* , Polina Koryagina a , Mikhail Tashkinov a , Vadim V. Silberschmidt b a Perm National Research Polytechnic University, Komsomoslky Ave. 29, Perm 614990, Russia b Loughborough University, Loughborough, Leicestershire LE11 3TU, UK

* Corresponding author. E-mail address: n.elenskaya@pstu.ru * Corresponding author. E-mail address: n.elenskaya@pstu.ru

2452-3216 © 2023 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of ICMD3M 2023 organizers 2452-3216 © 2023 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of ICMD3M 2023 organizers

2452-3216 © 2023 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of ICMD3M 2023 organizers 10.1016/j.prostr.2023.10.008