PSI - Issue 49

Available online at www.sciencedirect.com Available online at www.sciencedirect.com ScienceDirect Structural Integrity Procedia 00 (2023) 000 – 000

www.elsevier.com/locate/procedia

ScienceDirect

Procedia Structural Integrity 49 (2023) 3–9

© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of ICMD3M 2023 organizers Abstract Mass transport properties within 3D scaffold are essential for tissue regeneration; for example, various fluid environmental cues influence mesenchymal stem cells (MSCs) differentiation. 3D printing has been emerging as a new technology for scaffold fabrication by controlling the scaffold pore geometry to influence cell growth environment. Direct ink writing, one of the popular 3D printing methods, has the advantages of controlling the structure design and material selections. In this study, woodpile lattice tissue scaffold was fabricated using DIW method. The flow field within lattice scaffolds in a perfusion system was investigated with angles from 90  to 15  using the computational fluid dynamics (CFD) method. The results indicate that the maximum fluid velocity magnitude and fluid shear stress within the unit pore geometries of lattice structures increased as the angle decreased from 90  to 15  . The application of CFD techniques allowed a detailed prediction of velocity and fluid shear stress mapping within 3D printed scaffolds which is crucial to determine the optimal environment for cell and nutrient transport. © 2023 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of ICMD3M 2023 organizers Keywords: 3D printing; tissue scaffolds; pore shape; computational fluid dynamics. Medical Devices: Materials, Mechanics and Manufacturing 2nd International Conference on Medical Devices: Materials, Mechanics and Manufacturing (ICMD3M 2023) Computational fluid dynamics analysis of the fluid environment of 3D printed tissue scaffolds within a perfusion bioreactor: the effect of pore shape Bin Zhang a * a Department of Mechanical and Aerospace, Brunel University London, UK

* Corresponding author. Tel.: +44 1895 268573 E-mail address: bin.zhang@brunel.ac.uk

2452-3216 © 2023 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of ICMD3M 2023 organizers

2452-3216 © 2023 The Authors. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of ICMD3M 2023 organizers 10.1016/j.prostr.2023.10.002