PSI - Issue 15

Ran He et al. / Procedia Structural Integrity 15 (2019) 28–32 He et al. / Structural Integrity Procedia 00 (2019) 000–000

31

4

1

4.67 2.86

1.76

5.58 2.89

2.55

3.78

2.30

2.16

4.67

2.67

2.25

2

4.59 3.00

1.71

5.58 2.71

2.59

6.18

3.02

2.67

5.37

2.78

2.45

3

3.21 2.99

1.31

6.03 2.91

2.67

7.42

3.35

2.97

6.33

2.96

2.75

4

1.77 2.07

1.07

5.87 2.97

2.52

6.37

3.27

2.72

6.16

3.14

2.64

5

1.71 1.87

1.12

6.65 3.12

2.66

8.19

3.70

2.88

7.08

3.42

2.65

6

2.26 2.30

1.04

5.43 3.01

2.23

7.83

3.69

2.92

6.59

3.47

2.65

7

2.48 2.47

1.40

5.81 2.92

2.47

6.14

3.08

2.57

4.30

2.62

2.06

8

2.52 2.40

1.33

4.68 2.93

1.96

5.24

2.79

2.40

3.00

2.22

1.77

9

4.18 2.96

1.79

4.38 3.08

1.68

5.79

3.27

2.38

3.62

2.62

1.87

10

5.54 2.94

2.36

3.55 2.96

1.42

6.62

3.34

2.70

4.57

2.83

2.20

11

6.61 3.02

2.71

4.02 3.07

1.56

6.01

3.26

2.59

4.91

2.83

2.33

12

6.15 2.90

2.69

4.63 3.22

1.85

7.11

3.33

2.78

5.80

3.09

2.42

13

4.41 2.58

2.14

5.52 3.09

2.23

5.96

3.16

2.58

6.61

3.25

2.81

A, area (mm 2 ); MaxD, maximum diameter (mm); MinD, minimum diameter (mm).

4. Conclusions From the results of patient-specific simulations, it can be concluded that the plaque in this patient might be calcified as the simulations with a stiff plaque model were closer to clinical outcomes. The higher stress and damage in the stiff plaque caused by stenting indicated a higher risk of plaque rupture. Future work will include investigation of the effects of multiple stents and stent overlapping on the outcome of stent deployment. Acknowledgements We acknowledge the support from the EPSRC (EP/R001650/1), the British Heart Foundation (FS/15/21/31424) and the Royal Society of the UK (IE160066). References Fallen, C.T., Costello, J., Crawford, G., Schmidt, J.A., 2001. Measuring the Elastic Properties of Fine Wire. Journal of Biomedical Materials Research 58, 694–700. Fereidoonnezhad, B., Naghdabadi, R., Holzapfel, G.A., 2016. Stress Softening and Permanent Deformation in Human Aortas: Continuum and Computational Modeling with Application to Arterial Clamping. Journal of the Mechanical Behavior of Biomedical Materials 61, 600– 616. Foster Polymer Distribution. 2017. Pebax® 7433 SA 01 MED for Balloon Catheters. MatWeb. Han, K., Ishmaku, A., Xin, Y., Garmestani, H., Toplosky, V.J., Walsh, R., Swenson, C., Lesch, B., Ledbetter, H., Kim, S. Hundley, M., 2002. Mechanical Properties of MP35N as a Reinforcement Material for Pulsed Magnets. IEEE Transactions on Applied Superconductivity 12, 1244–47. Holzapfel, G.A., Sommer, G., Gasser, C.T., Regitnig, P., 2005. Determination of Layer-Specific Mechanical Properties of Human Coronary Arteries with Nonatherosclerotic Intimal Thickening and Related Constitutive Modeling. Heart and Circulatory Physiology 289, 2048–58. Ju, F., Xia, Z., Sasaki, K., 2008. On the Finite Element Modelling of Balloon-Expandable Stents. Journal of the Mechanical Behavior of Biomedical Materials 1, :86–95.