PSI - Issue 15

Available online at www.sciencedirect.com Structural Integrity Procedia 00 (2019) 000–000 Available online at www.sciencedirect.com ScienceDirect Structural Integrity Procedia 00 (2019) 000–000 ScienceDirect

www.elsevier.com/locate/procedia

www.elsevier.com/locate/procedia

ScienceDirect

Procedia Structural Integrity 15 (2019) 28–32

© 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) Selection and peer-review under responsibility of International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) Selection and peer-review under responsibility of International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. Ab tr ct This paper aims to investigate the utcomes of stent deployment in a patient-specific coronary artery using finite-element (FE) metho . Hyperelastic models with dam g , verifie against experimental results, wer used to describe stress-stretch response of arter al layers an plaque. Based o intravi al optical coherency tomography imaging of a specific patient’s coronary rtery, three-dimensional model of a diseased arter was dev oped, with two constitue t layers (media and adventitia) and plaque, using Mimics. The m del was meshed using 3-Matics nd then exported to FE software Abaqus. Abaqus CAE was used to create the models for off-the-shelf Resolute Integrity™ drug-eluting coronary stents and tri-folded expansion balloons. The effect of percutaneous coronary intervention on a lumen gain was investigated by simulating the deployment of stent, in comparison with the clinical res lt. © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) Selection and peer-review under responsibility of International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019 Finite Element Modelling of Stent Deployment in a Patient-specific Coronary Artery Ran He a , Liguo Zhao a, 0F * , Vadim V. Silberschmidt a , Yang Liu a , Felix Vogt b a Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Epinal Way, Loughborough, LE11 3TU, UK b Department of Cardiology, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany Abstract This paper aims to investigate the outcomes of stent deployment in a patient-specific coronary artery using finite-element (FE) method. Hyperelastic models with damage, verified against experimental results, were used to describe stress-stretch responses of arterial layers and plaque. Based on intravital optical coherency tomography imaging of a specific patient’s coronary artery, three-dimensional model of a diseased artery was developed, with two constituent layers (media and adventitia) and plaque, using Mimics. The model was meshed using 3-Matics and then exported to FE software Abaqus. Abaqus CAE was used to create the models for off-the-shelf Resolute Integrity™ drug-eluting coronary stents and tri-folded expansion balloons. The effect of percutaneous coronary intervention on a lumen gain was investigated by simulating the deployment of stent, in comparison with the clinical result. International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019 Finite Element Modelling of Stent Deplo ment in a Patient-specific Coronary Artery Ran He a , Liguo Zhao a, 0F * , Vadim V. Silberschmidt a , Yang Liu a , Felix Vogt b a Wolfson School of Mechanical, Electrical and Ma ufacturing Engineering, Loughborough University, Epinal Way, Loughborough, LE11 3TU, UK b Department of Cardiology, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany Keywords: Patient-specific; Finite element; Stent deployment; Multiple stents; Stent overlapping.

Keywords: Patient-specific; Finite element; Stent deployment; Multiple stents; Stent overlapping.

* Corresponding author. Tel.: 0044-1509-227799. E-mail address: L.Zhao@Lboro.ac.uk * Corresponding author. Tel.: 0044-1509-227799. E mail address: L.Zhao@Lboro.ac.uk

2452-3216 © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) Selection and peer-review under responsibility of International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. 2452-3216 © 2019 The Authors. Published b Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) Selection and peer-review under responsibility of International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019.

2452-3216  2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) Selection and peer-review under responsibility of International Conference on Stents: Materials, Mechanics and Manufacturing ICS3M 2019. 10.1016/j.prostr.2019.07.006