PSI - Issue 42

N.S. Hennicke et al. / Procedia Structural Integrity 42 (2022) 404–411 Author name / Structural Integrity Procedia 00 (2019) 000 – 000

410

7

Appendix A. Subject specific scaling factors

Table 3. Scaling factors for aging simulations

Femur Age group BMD at patients Z-score [g/cm²] Scaling factor T-score

20 – 29 30 – 39 40 – 49 50 – 59 60 – 69 70 – 79 20 – 29 30 – 39 40 – 49 50 – 59 60 – 69 70 – 79 80 +

0.961 0.945 0.911 0.898 0.869 0.832 0.758 0.757 0.742 0.714 0.697 0.649 0.619 0.532

1.27 1.25 1.20 1.19 1.15 1.10 1.22 1.20 1.15 1.13 1.05 1

-0.553 -0.668 -0.902 -0.990

1L

-1.19 -1.45 -1.97 -1.97 -2.08 -2.27 -2.39 -2.72 -2.93 -3.53

3L

1

80 +

0.860

Table 4. Scaling factors for osteoporosis simulations

Femur T-score BMD at T-score [g/cm²] Scaling factor

1.37 1.18 1.09

0

1.04

-1

0.897 0.825 0.753 0.681 0.609 0.897 0.825 0.753 0.681 0.609 1.04

-1.5

1L

0.993 0.898 0.803

-2

-2.5

-3

0

1.68 1.45 1.33 1.22 1.10

-1

-1.5

3L

-2

-2.5

-3

0.984

References Augat, P., Simon, U., Liedert, A., Claes, L., 2005. Mechanics and mechano-biology of fracture healing in normal and osteoporotic bone. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 16 Suppl 2, S36-43. Bauer, J.S., Link, T.M., 2009. Advances in osteoporosis imaging. European journal of radiology 71, 440 – 449. Compston, J.E., McClung, M.R., Leslie, W.D., 2019. Osteoporosis. The Lancet 393, 364 – 376. Cong, A., Buijs, J.O.D., Dragomir-Daescu, D., 2011. In situ parameter identification of optimal density-elastic modulus relationships in subject specific finite element models of the proximal femur. Medical engineering & physics 33, 164 – 173. El Miedany, Y., 2021. Recent developments towards closing the gap in osteoporosis management. Egyptian Rheumatology and Rehabilitation 48, 417.